AuthorsY. Yao, A. Zia, R. S. Neumann, M. Pavlovic, G. Balaban, K. E. A. Lundin, G. K. Sandve and S. Qiao
TitleT cell receptor repertoire as a potential diagnostic marker for celiac disease
AfilliationScientific Computing
Project(s)No Simula project
StatusPublished
Publication TypeJournal Article
Year of Publication2021
JournalClinical Immunology
Volume222
Date Published01/2021
PublisherElsevier
Abstract

An individual's T cell repertoire is skewed towards some specificities as a result of past antigen exposure and subsequent clonal expansion. Identifying T cell receptor signatures associated with a disease is challenging due to the overall complexity of antigens and polymorphic HLA allotypes. In celiac disease, the antigen epitopes are well characterised and the specific HLA-DQ2-restricted T-cell repertoire associated with the disease has been explored in depth. By investigating T cell receptor repertoires of unsorted lamina propria T cells from 15 individuals, we provide the first proof-of-concept study showing that it could be possible to infer disease state by matching against a priori known disease-associated T cell receptor sequences.

Citation Key28044